Methylation of p16 ink4a promoter is independent of human papillomavirus DNA physical state: a comparison between cervical pre-neoplastic and neoplastic samples

Methylation of p16 ink4a promoter is independent of human papillomavirus DNA physical state: a comparison between cervical pre-neoplastic and neoplastic samples

BACKGROUND Epigenetic modifications in host cells, like p16 ink4a methylation, have been considered as putative complementary mechanisms for cancer development. Because only a small proportion of infected women develop cervical cancer, other factors might be involved in carcinogenesis, either indep...

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Bibliographic Details
Main Authors: Fernanda Nahoum Carestiato, Sergio Menezes Amaro-Filho, Miguel Angelo Martins Moreira, Silvia Maria Baeta Cavalcanti
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2018-12-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
HPV16
cervical cancer
p16 ink4a
methylation
integration
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100301&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100301&lng=en&tlng=en

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