Role of cytoplasmic localization of maspin in promoting cell invasion in breast cancer with aggressive phenotype

Abstract Mammary serine protease inhibitor (maspin) is a tumor suppressor gene that is downregulated during carcinogenesis and breast cancer progression. While the nuclear localization of maspin is essential for tumor suppression, we previously reported that the cytoplasmic localization of maspin wa...

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Bibliographic Details
Main Authors: Tomohiko Sakabe, Makoto Wakahara, Goshi Shiota, Yoshihisa Umekita
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-90887-z