Minocycline Prevents the Development of Mechanical Allodynia in Mouse Models of Vincristine-Induced Peripheral Neuropathy

Minocycline Prevents the Development of Mechanical Allodynia in Mouse Models of Vincristine-Induced Peripheral Neuropathy

Vincristine is an antineoplastic substance that is part of many chemotherapy regimens, used especially for the treatment of a variety of pediatric cancers including leukemias and brain tumors. Unfortunately, many vincristine-treated patients develop peripheral neuropathy, a side effect characterized...

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Bibliographic Details
Main Authors: H. Starobova, A. Mueller, R. Allavena, R. J. Lohman, M. J. Sweet, I. Vetter
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neuroscience
Subjects:
neuropathic pain
chemotherapy
neuro-inflammation
vincristine
minocycline
toll-like receptor 4
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00653/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00653/full

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