TGF-β1 Suppresses Proliferation and Induces Differentiation in Human iPSC Neural in vitro Models

TGF-β1 Suppresses Proliferation and Induces Differentiation in Human iPSC Neural in vitro Models

Persistent neural stem cell (NSC) proliferation is, among others, a hallmark of immaturity in human induced pluripotent stem cell (hiPSC)-based neural models. TGF-β1 is known to regulate NSCs in vivo during embryonic development in rodents. Here we examined the role of TGF-β1 as a potential candidat...

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Bibliographic Details
Main Authors: Julia Izsak, Dzeneta Vizlin-Hodzic, Margarita Iljin, Joakim Strandberg, Janusz Jadasz, Thomas Olsson Bontell, Stephan Theiss, Eric Hanse, Hans Ågren, Keiko Funa, Sebastian Illes
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
human induced pluripotent stem cells
neural stem cells
neural differentiation
cortical development
TGF-β1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.571332/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.571332/full

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