The Critical Roles and Mechanisms of Immune Cell Death in Sepsis

The Critical Roles and Mechanisms of Immune Cell Death in Sepsis

Sepsis was first described by the ancient Greek physicians over 2000 years ago. The pathophysiology of the disease, however, is still not fully understood and hence the mortality rate is still unacceptably high due to lack of specific therapies. In the last decade, great progress has been made by sh...

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Bibliographic Details
Main Authors: Zhenxing Cheng, Simon T. Abrams, Julien Toh, Susan Siyu Wang, Zhi Wang, Qian Yu, Weiping Yu, Cheng-Hock Toh, Guozheng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
sepsis
extensive immune cell death
damage-associated molecular patterns (DAMPs)
multiple organ dysfunction syndrome (MODS)
extracellular histones
immunosuppression
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01918/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01918/full

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