Enhanced dentate gyrus synaptic plasticity but reduced neurogenesis in a mouse model of amyloidosis

Enhanced dentate gyrus synaptic plasticity but reduced neurogenesis in a mouse model of amyloidosis

Long-term potentiation (LTP) and neurogenesis in the dentate gyrus (DG) are correlated forms of hippocampal plasticity which share, under physiological conditions, common regulatory mechanisms. In Alzheimer's disease (AD), their alterations are potentially associated with the early cellular pat...

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Bibliographic Details
Main Authors: Raphaël Poirier, Inge Veltman, Marie Claire Pflimlin, Frédéric Knoflach, Friedrich Metzger
Format: Article
Language:English
Published: Elsevier 2010-11-01
Series:Neurobiology of Disease
Subjects:
Alzheimer
Neurogenesis
LTP
Potentiation
Dentate gyrus
Presenilin
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611000210X

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http://www.sciencedirect.com/science/article/pii/S096999611000210X

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