Identification of 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma

Identification of 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma

Glycine N-methyltransferase (GNMT) expression is vastly downregulated in hepatocellular carcinomas (HCC). High rates of GNMT knockout mice developed HCC, while overexpression of GNMT prevented aflatoxin-induced carcinogenicity and inhibited liver cancer cell proliferation. Therefore, in this study,...

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Bibliographic Details
Main Authors: Rajni Kant, Chia-Hung Yen, Chung-Kuang Lu, Ying-Chi Lin, Jih-Heng Li, Yi-Ming Arthur Chen
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:International Journal of Molecular Sciences
Subjects:
glycine N-methyltransferase (GNMT)
hepatocellular carcinomas (HCC)
1,2,3,4,6-penta-O-galloyl-β-
">d-glucopyranoside (PGG)
sorafenib
high-throughput screening (HTS)
Online Access:http://www.mdpi.com/1422-0067/17/5/669

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http://www.mdpi.com/1422-0067/17/5/669

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