Reductions in Myeloid-Derived Suppressor Cells and Lung Metastases using AZD4547 Treatment of a Metastatic Murine Breast Tumor Model

Reductions in Myeloid-Derived Suppressor Cells and Lung Metastases using AZD4547 Treatment of a Metastatic Murine Breast Tumor Model

Background: AZD4547, a small-molecule inhibitor targeting the tyrosine kinase of Fibroblast Growth Factor Receptors (FGFRs), is currently under phase II clinical study for human subjects having breast cancer, while the underlying mechanism remains elusive. The aim of this study is to explore the pot...

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Bibliographic Details
Main Authors: Li Liu, Ting Hong Ye, Yuan Ping Han, Hang Song, Yong Kui Zhang, Yong Xia, Ning Yu Wang, Ying Xiong, Xue Jiao Song, Yong Xia Zhu, De Liang Li, Jun Zeng, Kai Ran, Cui Ting Peng, Yu Quan Wei, Luo Ting Yu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
FGFR inhibitor
Breast cancer
AZD4547
Metastasis
MDSCs
T cells
Online Access:http://www.karger.com/Article/FullText/358640

Internet

http://www.karger.com/Article/FullText/358640

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