Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury

Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury

Abstract Background Inflammatory response mediated by oxidative stress is considered as an important pathogenesis of spinal cord injury (SCI). Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress and their role in inflammatory response after SCI remained unclear. This st...

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Bibliographic Details
Main Authors: Zhongyuan Liu, Xinqiang Yao, Wangsheng Jiang, Wei Li, Siyuan Zhu, Congrui Liao, Lin Zou, Ruoting Ding, Jianting Chen
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Neuroinflammation
Subjects:
Advanced oxidation protein products
Inflammatory response
Spinal cord injury
ROS-dependent
MAPKs-NF-κB signaling pathway
NLRP3-mediated pyroptosis
Online Access:http://link.springer.com/article/10.1186/s12974-020-01751-2

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http://link.springer.com/article/10.1186/s12974-020-01751-2

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