Negative Allosteric Modulators of mGlu7 Receptor as Putative Antipsychotic Drugs

Negative Allosteric Modulators of mGlu7 Receptor as Putative Antipsychotic Drugs

The data concerning antipsychotic-like activity of negative allosteric modulators (NAMs)/antagonists of mGlu7 receptors are limited. The only available ligands for this receptor are MMPIP and ADX71743. In the present studies, we used stable cell line expressing mGlu7 receptor and it was shown that b...

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Bibliographic Details
Main Authors: Paulina Cieślik, Monika Woźniak, Katarzyna Kaczorowska, Piotr Brański, Grzegorz Burnat, Agnieszka Chocyk, Bartosz Bobula, Piotr Gruca, Ewa Litwa, Agnieszka Pałucha-Poniewiera, Agnieszka Wąsik, Andrzej Pilc, Joanna Wierońska
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
schizophrenia
metabotropic glutamate receptor 7
antipsychotic
negative allosteric modulators
MMPIP
ADX71743
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00316/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00316/full

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