A Dual Role of P53 in Regulating Colistin-Induced Autophagy in PC-12 Cells

A Dual Role of P53 in Regulating Colistin-Induced Autophagy in PC-12 Cells

This study aimed to investigate the mechanism of p53 in regulating colistin-induced autophagy in PC-12 cells. Importantly, cells were treated with 125 μg/ml colistin for 12 and 24 h after transfection with p53 siRNA or recombinant plasmid. The hallmarks of autophagy and apoptosis were examined by re...

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Bibliographic Details
Main Authors: Ziyin Lu, Chunli Chen, Zhiyong Wu, Yusong Miao, Ishfaq Muhammad, Liangjun Ding, Erjie Tian, Wanjun Hu, Huilin Ni, Rui Li, Bo Wang, Jichang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Pharmacology
Subjects:
colistin
autophagy
p53
PC-12 cells
apoptosis
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00768/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00768/full

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