Loss of Sympathetic Nerves in Spleens from Patients with End Stage Sepsis

The spleen is an important site for central regulation of immune function by noradrenergic sympathetic nerves, but little is known about this major region of neuroimmune communication in humans. Experimental studies using animal models have established that sympathetic innervation of the spleen is e...

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Bibliographic Details
Main Authors: Donald B. Hoover, Thomas Christopher Brown, Madeleine K. Miller, John B. Schweitzer, David L. Williams
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01712/full