Granisetron attenuates liver injury and inflammation in a rat model of cecal ligation and puncture-induced sepsis

Background and aims: Sepsis induced liver injury is recognized as a serious complication in intensive care units, it is deeply associated with oxidative stress, inflammation and subsequent pyroptosis. Hepatic pyroptosis known to aggravate sepsis-induced liver injury. Previous studies proved that gra...

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Bibliographic Details
Main Authors: Amira M. Aboyoussef, Mostafa Kamal Mohammad, Ali Ahmed Abo-Saif, Basim A.S. Messiha
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Journal of Pharmacological Sciences
Subjects:
CLP
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000803