CAR T cells in solid tumors: challenges and opportunities

CAR T cells in solid tumors: challenges and opportunities

Abstract Background CARs are simulated receptors containing an extracellular single-chain variable fragment (scFv), a transmembrane domain, as well as an intracellular region of immunoreceptor tyrosine-based activation motifs (ITAMs) in association with a co-stimulatory signal. Main body Chimeric an...

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Bibliographic Details
Main Authors: Faroogh Marofi, Roza Motavalli, Vladimir A. Safonov, Lakshmi Thangavelu, Alexei Valerievich Yumashev, Markov Alexander, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Mostafa Jarahian, Sepideh Izadi, Ali Hassanzadeh, Naghmeh Shirafkan, Safa Tahmasebi, Farhad Motavalli Khiavi
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Stem Cell Research & Therapy
Subjects:
Chimeric antigen receptor
Solid tumors
CAR T cells
Cell therapy
Online Access:https://doi.org/10.1186/s13287-020-02128-1

Internet

https://doi.org/10.1186/s13287-020-02128-1

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