Mimulone-induced autophagy through p53-mediated AMPK/mTOR pathway increases caspase-mediated apoptotic cell death in A549 human lung cancer cells.

Mimulone-induced autophagy through p53-mediated AMPK/mTOR pathway increases caspase-mediated apoptotic cell death in A549 human lung cancer cells.

Anticancer properties and mechanisms of mimulone (MML), C-geranylflavonoid isolated from the Paulownia tomentosa fruits, were firstly elucidated in this study. MML prevented cell proliferation in a dose- and time-dependent way and triggered apoptosis through the extrinsic pathway in A549 human lung...

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Bibliographic Details
Main Authors: Hyun-Kyu An, Kyoung-Sook Kim, Ji-Won Lee, Mi-Hyun Park, Hyung-In Moon, Shin-Ji Park, Ji-Sue Baik, Cheorl-Ho Kim, Young-Choon Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4260910?pdf=render

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http://europepmc.org/articles/PMC4260910?pdf=render

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