Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding

Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding

B lymphocytes use B cell receptors (BCRs) to recognize antigens. It is still not clear how BCR transduces antigen-specific physical signals upon binding across cell membrane for the conversion to chemical signals, triggering downstream signaling cascades. It is hypothesized that through a series of...

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Bibliographic Details
Main Authors: Zhixun Shen, Sichen Liu, Xinxin Li, Zhengpeng Wan, Youxiang Mao, Chunlai Chen, Wanli Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
B cell receptor
BCR activation
conformational change
FRET
Online Access:https://elifesciences.org/articles/42271

Internet

https://elifesciences.org/articles/42271

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