Urate-induced epigenetic modifications in myeloid cells

Urate-induced epigenetic modifications in myeloid cells

Abstract Objectives Hyperuricemia is a metabolic condition central to gout pathogenesis. Urate exposure primes human monocytes towards a higher capacity to produce and release IL-1β. In this study, we assessed the epigenetic processes associated to urate-mediated hyper-responsiveness. Methods Freshl...

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Bibliographic Details
Main Authors: M. Badii, O. I. Gaal, M. C. Cleophas, V. Klück, R. Davar, E. Habibi, S. T. Keating, B. Novakovic, M. M. Helsen, N. Dalbeth, L. K. Stamp, D. Macartney-Coxson, A. J. Phipps-Green, H. G. Stunnenberg, C. A. Dinarello, T. R. Merriman, M. G. Netea, T. O. Crişan, L. A. B. Joosten
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Arthritis Research & Therapy
Subjects:
Hyperuricemia
Cytokines
Epigenetics
DNA methylation
Gout
Online Access:https://doi.org/10.1186/s13075-021-02580-1

Internet

https://doi.org/10.1186/s13075-021-02580-1

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