Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a 1H-NMR Method to Assess Deacetylase Activity

Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a 1H-NMR Method to Assess Deacetylase Activity

The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases. Here we describe SAR studies starting from the unselective sirtuin inhibitor tenovin-6. These studies identify a sub...

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Bibliographic Details
Main Authors: Nicholas J. Westwood, Sonia Lain, Tomas Lebl, Daumantas Matulis, Asta Zubrienė, Anna R. McCarthy, Louise L. Major, Vaida Morkūnaitė, Lisa Pirrie
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:Molecules
Subjects:
sirtuin
chemical tool
deacetylase assay
neurodegenerative diseases
Online Access:http://www.mdpi.com/1420-3049/17/10/12206

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http://www.mdpi.com/1420-3049/17/10/12206

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