Mitochondrial bioenergetics of metastatic breast cancer cells in response to dynamic changes in oxygen tension: effects of HIF-1α.

Mitochondrial bioenergetics of metastatic breast cancer cells in response to dynamic changes in oxygen tension: effects of HIF-1α.

Solid tumors are characterized by regions of low oxygen tension (OT), which play a central role in tumor progression and resistance to therapy. Low OT affects mitochondrial function and for the cells to survive, mitochondria must functionally adapt to low OT to maintain the cellular bioenergetics. I...

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Bibliographic Details
Main Authors: Anne R Diers, Praveen K Vayalil, Claudia R Oliva, Corinne E Griguer, Victor Darley-Usmar, Douglas R Hurst, Danny R Welch, Aimee Landar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3696014?pdf=render

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http://europepmc.org/articles/PMC3696014?pdf=render

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