Enhanced Ca2+-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model

Enhanced Ca2+-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model

Huntington's disease (HD) causes preferential loss of a subset of neurons in the brain although the huntingtin protein is expressed broadly in various neural cell types, including astrocytes. Glutamate-mediated excitotoxicity is thought to cause selective neuronal injury, and brain astrocytes h...

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Bibliographic Details
Main Authors: William Lee, Reno C. Reyes, Manoj K. Gottipati, Karon Lewis, Mathieu Lesort, Vladimir Parpura, Michelle Gray
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Astrocytes
Glutamate
Pyruvate carboxylase
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113001691

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http://www.sciencedirect.com/science/article/pii/S0969996113001691

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