Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis

Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis

RAS genes are among the most frequently mutated proto-oncogenes in cancer. However, how Ras stability is regulated remains largely unknown. Here, we report a regulatory loop involving the E3 ligase Nedd4-1, Ras, and PTEN. We found that Ras signaling stimulates the expression of Nedd4-1, which in tur...

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Bibliographic Details
Main Authors: Taoling Zeng, Qun Wang, Jieying Fu, Qi Lin, Jing Bi, Weichao Ding, Yikai Qiao, Sheng Zhang, Wenxiu Zhao, Huayue Lin, Meilin Wang, Binfeng Lu, Xianming Deng, Dawang Zhou, Zhenyu Yin, Hong-Rui Wang
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714002423

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http://www.sciencedirect.com/science/article/pii/S2211124714002423

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