Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins

Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins

Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically regulates mast cell responses to complement anaphyl...

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Bibliographic Details
Main Authors: Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
mast cells
complement C3a
complement C5a
complement
degranulation
interleukin-33
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.615236/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.615236/full

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