Hypertension-linked mutation of α-adducin increases CFTR surface expression and activity in HEK and cultured rat distal convoluted tubule cells.

Hypertension-linked mutation of α-adducin increases CFTR surface expression and activity in HEK and cultured rat distal convoluted tubule cells.

The CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) activity and localization are influenced by the cytoskeleton, in particular by actin and its polymerization state. In this study we investigated whether the expression of the hypertensive mutations of α-adducin (G460W-S586C in humans, F3...

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Main Authors: Anna Mondini, Francesca Sassone, Davide Antonio Civello, Maria Lisa Garavaglia, Claudia Bazzini, Simona Rodighiero, Valeria Vezzoli, Fabio Conti, Lucia Torielli, Giovanbattista Capasso, Markus Paulmichl, Giuliano Meyer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3528715?pdf=render

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http://europepmc.org/articles/PMC3528715?pdf=render

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