Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy.

Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy.

Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by genetic and environmental factors. Abnormal accumulation and aggregation of alpha-synuclein (a-syn) within neurons, and mutations in the a-syn and UCH-L1 genes have been shown to play a role in the pathogenesis of PD...

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Bibliographic Details
Main Authors: Anna E Cartier, Kiren Ubhi, Brian Spencer, Ruben A Vazquez-Roque, Kori Ann Kosberg, Lawrence Fourgeaud, Priya Kanayson, Christina Patrick, Edward Rockenstein, Gentry N Patrick, Eliezer Masliah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3326048?pdf=render

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http://europepmc.org/articles/PMC3326048?pdf=render

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