Safe CRISPR-Cas9 Inhibition of HIV-1 with High Specificity and Broad-Spectrum Activity by Targeting LTR NF-κB Binding Sites

Safe CRISPR-Cas9 Inhibition of HIV-1 with High Specificity and Broad-Spectrum Activity by Targeting LTR NF-κB Binding Sites

Viral latency of human immunodeficiency virus type 1 (HIV-1) has become a major hurdle to a cure in the highly effective antiretroviral therapy (ART) era. The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system has successfully been demonstrated to excise or inactivate int...

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Bibliographic Details
Main Authors: Cheng-Han Chung, Alexander G. Allen, Andrew J. Atkins, Neil T. Sullivan, Greg Homan, Robert Costello, Rebekah Madrid, Michael R. Nonnemacher, Will Dampier, Brian Wigdahl
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
gene therapy
HIV-1 reservoir
CRISPR-Cas9
NF-κB
computational biology
GUIDE-Seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302055

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http://www.sciencedirect.com/science/article/pii/S2162253120302055

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