Intact spatial memory in mice with seizure-induced partial lossof hippocampal pyramidal neurons

We generated defined neuronal loss in hippocampus of genetically identical mice by pilocarpine injections and studied the impact of these seizures on the performance of mice in spatial learning and memory. The numbers of TUNEL-positive degenerating cells paralleled the severity of the seizures. When...

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Bibliographic Details
Main Authors: M.Hasan Mohajeri, Krishan Saini, Hong Li, Arames Crameri, Hans-Peter Lipp, David P Wolfer, Roger M Nitsch
Format: Article
Language:English
Published: Elsevier 2003-04-01
Series:Neurobiology of Disease
Subjects:
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Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102000311