Upregulation of immunoproteasome subunits in myositis indicates active inflammation with involvement of antigen presenting cells, CD8 T-cells and IFNΓ.

Upregulation of immunoproteasome subunits in myositis indicates active inflammation with involvement of antigen presenting cells, CD8 T-cells and IFNΓ.

OBJECTIVE: In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and upregulation of MHC-I expression implies increased antigen presentation and involvement of the proteasome system. To decipher the role of immunoproteasomes in myositis, we investigated individual cell...

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Bibliographic Details
Main Authors: Khetam Ghannam, Lorena Martinez-Gamboa, Lydia Spengler, Sabine Krause, Biljana Smiljanovic, Marc Bonin, Salyan Bhattarai, Andreas Grützkau, Gerd-R Burmester, Thomas Häupl, Eugen Feist
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4123911?pdf=render

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http://europepmc.org/articles/PMC4123911?pdf=render

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