Cyclic Stretch Induces Inducible Nitric Oxide Synthase and Soluble Guanylate Cyclase in Pulmonary Artery Smooth Muscle Cells

Cyclic Stretch Induces Inducible Nitric Oxide Synthase and Soluble Guanylate Cyclase in Pulmonary Artery Smooth Muscle Cells

In the pulmonary vasculature, mechanical forces such as cyclic stretch induce changes in vascular signaling, tone and remodeling. Nitric oxide is a potent regulator of soluble guanylate cyclase (sGC), which drives cGMP production, causing vasorelaxation. Pulmonary artery smooth muscle cells (PASMCs)...

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Bibliographic Details
Main Authors: Kathryn N. Farrow, Paul T. Schumacker, Robin H. Steinhorn, Satyan Lakshminrusimha, Gina A. Kim, Lyubov Czech, Stephen Wedgwood, Monica R. Shah
Format: Article
Language:English
Published: MDPI AG 2013-02-01
Series:International Journal of Molecular Sciences
Subjects:
pulmonary vasculature
cyclic stretch
sGC
reactive oxygen species
iNOS
Online Access:http://www.mdpi.com/1422-0067/14/2/4334

Internet

http://www.mdpi.com/1422-0067/14/2/4334

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