N-acetyltransferase 2 (NAT2) gene polymorphism as a predisposing factor for phenytoin intoxication in tuberculous meningitis or tuberculoma patients having seizures - A pilot study

N-acetyltransferase 2 (NAT2) gene polymorphism as a predisposing factor for phenytoin intoxication in tuberculous meningitis or tuberculoma patients having seizures - A pilot study

Background & objectives: Simultaneous administration of phenytoin and isoniazid (INH) in tuberculous meningitis (TBM) or tuberculoma patients with seizures results in higher plasma phenytoin level and thus phenytoin intoxication. N-acetyltransferase 2 (NAT2) enzyme catalyses two acetylation reac...

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Bibliographic Details
Main Authors: Prashant S Adole, Parampreet S Kharbanda, Sadhna Sharma
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Indian Journal of Medical Research
Subjects:
Adverse drug interaction - NAT2 gene polymorphism - phenytoin intoxication - rapid acetylator genotypes - seizures - tuberculoma - tuberculous meningitis
Online Access:http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2016;volume=143;issue=5;spage=581;epage=590;aulast=Adole

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http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2016;volume=143;issue=5;spage=581;epage=590;aulast=Adole

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