Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1

Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1

Summary: Enhanced stemness in colorectal cancer has been reported and it contributes to aggressive progression, but the underlying mechanisms remain unclear. Here we report a Wnt ligand, Dickkopf-2 (DKK2) is essential for developing colorectal cancer stemness. Genetic depletion of DKK2 in intestinal...

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Bibliographic Details
Main Authors: Jae Hun Shin, Jaekwang Jeong, Jungmin Choi, Jaechul Lim, Ravi K. Dinesh, Jonathan Braverman, Jun Young Hong, Stephen E. Maher, Maria C. Amezcua Vesely, WonJu Kim, Ja-Hyun Koo, Wenwen Tang, Dianqing Wu, Holly N. Blackburn, Rosa M. Xicola, Xavier Llor, Omer Yilmaz, Je-Min Choi, Alfred L.M. Bothwell
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:iScience
Subjects:
Cell Biology
Stem Cells Research
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221003795

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http://www.sciencedirect.com/science/article/pii/S2589004221003795

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