Chronic intermittent hypobaric hypoxia attenuates monocrotaline-induced pulmonary arterial hypertension via modulating inflammation and suppressing NF-κB /p38 pathway

Chronic intermittent hypobaric hypoxia attenuates monocrotaline-induced pulmonary arterial hypertension via modulating inflammation and suppressing NF-κB /p38 pathway

Objective(s): Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reportedto be associated with many inflammatory mediators of PAH. This study aim...

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Bibliographic Details
Main Authors: Lei Gao, Jun Liu, Yongmei Hao, Zengren Zhao, Huilian Tan, Jie Zhang, Ning Meng, Qinghou Zheng, Zhen Wang, Yi Zhang
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2018-03-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Chronic intermittent
hypobaric hypoxia Inflammation Monocrotaline NFκB Pulmonary arterial
hypertension p38 MAPK
Online Access:http://ijbms.mums.ac.ir/article_10192_b35277665bef3559a5f2f8fbad351a7d.pdf

Internet

http://ijbms.mums.ac.ir/article_10192_b35277665bef3559a5f2f8fbad351a7d.pdf

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