Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Recent studies suggest that extracellular cGAMP can be taken up by macrophages to engage STING through several mechanisms. Our work demonstrates that connexin-dependent communication between epithelial cells and macrophages plays a significant role in the amplification of antiviral responses mediate...

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Bibliographic Details
Main Authors: Geneviève Pépin, Dominic De Nardo, Christina L. Rootes, Tomalika R. Ullah, Sumaiah S. Al-Asmari, Katherine R. Balka, Hong-Mei Li, Kylie M. Quinn, Fiona Moghaddas, Stephane Chappaz, Benjamin T. Kile, Eric F. Morand, Seth L. Masters, Cameron R. Stewart, Bryan R. G. Williams, Michael P. Gantier
Format: Article
Language:English
Published: American Society for Microbiology 2020-01-01
Series:mBio
Subjects:
connexins
sting
cgamp
cgas
Online Access:https://doi.org/10.1128/mBio.03187-19

Internet

https://doi.org/10.1128/mBio.03187-19

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