Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-κB pathway through microbiota–gut–brain axis

Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-κB pathway through microbiota–gut–brain axis

Parkinson's disease (PD) is the second most common neurodegenerative disease, but none of the current treatments for PD can halt the progress of the disease due to the limited understanding of the pathogenesis. In PD development, the communication between the brain and the gastrointestinal syst...

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Bibliographic Details
Main Authors: Zhe Zhao, Fangyuan Li, Jingwen Ning, Ran Peng, Junmei Shang, Hui Liu, Meiyu Shang, Xiu-Qi Bao, Dan Zhang
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
FLZ
Microbiota–gut–brain axis
Parkinson's disease
Rotenone mouse model
TLR4/MyD88/NF-κB pathway
Gastrointestinal dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521000915

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http://www.sciencedirect.com/science/article/pii/S2211383521000915

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