Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility

Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility

Antibody-drug conjugates (ADCs) offer a combination of antibody therapy and specific delivery of potent small-molecule payloads to target cells. The properties of the ADC molecule are determined by the balance of its components. The efficacy of the payload component increases with higher drug-to-ant...

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Bibliographic Details
Main Authors: Tero Satomaa, Henna Pynnönen, Anja Vilkman, Titta Kotiranta, Virve Pitkänen, Annamari Heiskanen, Bram Herpers, Leo S. Price, Jari Helin, Juhani Saarinen
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Antibodies
Subjects:
glycoside
auristatin
MMAE
MMAU
ADC
hydrophilicity
therapeutic window
Online Access:http://www.mdpi.com/2073-4468/7/2/15

Internet

http://www.mdpi.com/2073-4468/7/2/15

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