Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1

Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1

Psoriasis is a complex human-specific disease characterized by perturbed keratinocyte proliferation and a pro-inflammatory environment in the skin. Porcine skin architecture and immunity are very similar to that in humans, rendering the pig a suitable animal model for studying the biology and treatm...

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Bibliographic Details
Main Authors: Nicklas Heine Staunstrup, Karin Stenderup, Sidsel Mortensen, Maria Nascimento Primo, Cecilia Rosada, Torben Steiniche, Ying Liu, Rong Li, Mette Schmidt, Stig Purup, Frederik Dagnæs-Hansen, Lisbeth Dahl Schrøder, Lars Svensson, Thomas Kongstad Petersen, Henrik Callesen, Lars Bolund, Jacob Giehm Mikkelsen
Format: Article
Language:English
Published: The Company of Biologists 2017-07-01
Series:Disease Models & Mechanisms
Subjects:
DNA transposition
Integrin
Pig cloning
Psoriasis
Skin inflammation
Sleeping Beauty
Online Access:http://dmm.biologists.org/content/10/7/869

Internet

http://dmm.biologists.org/content/10/7/869

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