Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1
Psoriasis is a complex human-specific disease characterized by perturbed keratinocyte proliferation and a pro-inflammatory environment in the skin. Porcine skin architecture and immunity are very similar to that in humans, rendering the pig a suitable animal model for studying the biology and treatm...
Main Authors: | Nicklas Heine Staunstrup, Karin Stenderup, Sidsel Mortensen, Maria Nascimento Primo, Cecilia Rosada, Torben Steiniche, Ying Liu, Rong Li, Mette Schmidt, Stig Purup, Frederik Dagnæs-Hansen, Lisbeth Dahl Schrøder, Lars Svensson, Thomas Kongstad Petersen, Henrik Callesen, Lars Bolund, Jacob Giehm Mikkelsen |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2017-07-01
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Series: | Disease Models & Mechanisms |
Subjects: | |
Online Access: | http://dmm.biologists.org/content/10/7/869 |
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