Complementary LC-MS/MS-Based N-Glycan, N-Glycopeptide, and Intact N-Glycoprotein Profiling Reveals Unconventional Asn71-Glycosylation of Human Neutrophil Cathepsin G

Complementary LC-MS/MS-Based N-Glycan, N-Glycopeptide, and Intact N-Glycoprotein Profiling Reveals Unconventional Asn71-Glycosylation of Human Neutrophil Cathepsin G

Neutrophil cathepsin G (nCG) is a central serine protease in the human innate immune system, but the importance of its N-glycosylation remains largely undescribed. To facilitate such investigations, we here use complementary LC-MS/MS-based N-glycan, N-glycopeptide, and intact glycoprotein profiling...

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Bibliographic Details
Main Authors: Ian Loke, Nicolle H. Packer, Morten Thaysen-Andersen
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Biomolecules
Subjects:
neutrophil
cathepsin G
N-glycan
glycopeptide
glycoprotein
chitobiose
paucimannose
N-acetylglucosamine
glycomics
azurophilic granule
Online Access:http://www.mdpi.com/2218-273X/5/3/1832

Internet

http://www.mdpi.com/2218-273X/5/3/1832

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