Paclitaxel inhibits mRNA transport in axons

Paclitaxel inhibits mRNA transport in axons

Paclitaxel is an integral component of solid tumor treatment. This chemotherapeutic agent provokes an often irreversible peripheral sensory neuropathy with pathological features of distal axonal degeneration. Current pathological concepts assume that polymerization of axonal microtubules and mitocho...

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Bibliographic Details
Main Authors: Ilja Bobylev, Abhijeet R. Joshi, Mohammed Barham, Christian Ritter, Wolfram F. Neiss, Ahmet Höke, Helmar C. Lehmann
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Axonal transport
Taxol
Chemotherapy
Neuropathy
Microtubule
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300103

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http://www.sciencedirect.com/science/article/pii/S0969996115300103

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