Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis

Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis

Leishmania parasites infect macrophages, causing a wide spectrum of human diseases, from cutaneous to visceral forms. In search of novel therapeutic targets, we performed comprehensive in vitro and ex vivo mapping of the signaling pathways upstream and downstream of antioxidant transcription factor...

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Bibliographic Details
Main Authors: Áislan de Carvalho Vivarini, Teresa Cristina Calegari-Silva, Alessandra Mattos Saliba, Viviane Sampaio Boaventura, Jaqueline França-Costa, Ricardo Khouri, Tim Dierckx, Karina Luiza Dias-Teixeira, Nicolas Fasel, Aldina Maria Prado Barral, Valéria Matos Borges, Johan Van Weyenbergh, Ulisses Gazos Lopes
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
Leishmania
macrophage
nuclear factor erythroid 2-related factor 2
PKR
Sod1
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01127/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01127/full

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