The Significance of Discordant Serology in Chagas Disease: Enhanced T-Cell Immunity to Trypanosoma cruzi in Serodiscordant Subjects

The Significance of Discordant Serology in Chagas Disease: Enhanced T-Cell Immunity to Trypanosoma cruzi in Serodiscordant Subjects

BackgroundSubjects are considered infected with Trypanosoma cruzi when tested positive by at least two out of three serological tests, whereas a positive result in only one of up to three tests is termed “serodiscordant” (SD). Assessment of parasite-specific T-cell responses may help discriminate th...

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Bibliographic Details
Main Authors: Melisa D. Castro Eiro, María G. Alvarez, Gretchen Cooley, Rodolfo J. Viotti, Graciela L. Bertocchi, Bruno Lococo, María C. Albareda, Ana M. De Rissio, María A. Natale, Cecilia Parodi, Rick L. Tarleton, Susana A. Laucella
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
Trypanosoma cruzi
serodiscordance
T cells
multiplex assay
polyfunctionality
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01141/full

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