Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels

Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels

TREK/TRAAK channels are polymodal K+ channels that convert very diverse stimuli, including bioactive lipids, mechanical stretch and temperature, into electrical signals. The nature of the structural changes that regulate their activity remains an open question. Here, we show that a cytoplasmic domai...

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Bibliographic Details
Main Authors: Ismail Ben Soussia, Frank S. Choveau, Sandy Blin, Eun-Jin Kim, Sylvain Feliciangeli, Franck C. Chatelain, Dawon Kang, Delphine Bichet, Florian Lesage
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
potassium channel
resting membrane potential
excitability
PIP2 – phosphatidylinositol-4
5-bisphosphate
structure function analysis
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00301/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00301/full

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