Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specific bacterial genetic variation associated with susc...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09976-3 |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
John A. Lees Bart Ferwerda Philip H. C. Kremer Nicole E. Wheeler Mercedes Valls Serón Nicholas J. Croucher Rebecca A. Gladstone Hester J. Bootsma Nynke Y. Rots Alienke J. Wijmega-Monsuur Elisabeth A. M. Sanders Krzysztof Trzciński Anne L. Wyllie Aeilko H. Zwinderman Leonard H. van den Berg Wouter van Rheenen Jan H. Veldink Zitta B. Harboe Lene F. Lundbo Lisette C. P. G. M. de Groot Natasja M. van Schoor Nathalie van der Velde Lars H. Ängquist Thorkild I. A. Sørensen Ellen A. Nohr Alexander J. Mentzer Tara C. Mills Julian C. Knight Mignon du Plessis Susan Nzenze Jeffrey N. Weiser Julian Parkhill Shabir Madhi Thomas Benfield Anne von Gottberg Arie van der Ende Matthijs C. Brouwer Jeffrey C. Barrett Stephen D. Bentley Diederik van de Beek |
| spellingShingle |
John A. Lees Bart Ferwerda Philip H. C. Kremer Nicole E. Wheeler Mercedes Valls Serón Nicholas J. Croucher Rebecca A. Gladstone Hester J. Bootsma Nynke Y. Rots Alienke J. Wijmega-Monsuur Elisabeth A. M. Sanders Krzysztof Trzciński Anne L. Wyllie Aeilko H. Zwinderman Leonard H. van den Berg Wouter van Rheenen Jan H. Veldink Zitta B. Harboe Lene F. Lundbo Lisette C. P. G. M. de Groot Natasja M. van Schoor Nathalie van der Velde Lars H. Ängquist Thorkild I. A. Sørensen Ellen A. Nohr Alexander J. Mentzer Tara C. Mills Julian C. Knight Mignon du Plessis Susan Nzenze Jeffrey N. Weiser Julian Parkhill Shabir Madhi Thomas Benfield Anne von Gottberg Arie van der Ende Matthijs C. Brouwer Jeffrey C. Barrett Stephen D. Bentley Diederik van de Beek Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis Nature Communications |
| author_facet |
John A. Lees Bart Ferwerda Philip H. C. Kremer Nicole E. Wheeler Mercedes Valls Serón Nicholas J. Croucher Rebecca A. Gladstone Hester J. Bootsma Nynke Y. Rots Alienke J. Wijmega-Monsuur Elisabeth A. M. Sanders Krzysztof Trzciński Anne L. Wyllie Aeilko H. Zwinderman Leonard H. van den Berg Wouter van Rheenen Jan H. Veldink Zitta B. Harboe Lene F. Lundbo Lisette C. P. G. M. de Groot Natasja M. van Schoor Nathalie van der Velde Lars H. Ängquist Thorkild I. A. Sørensen Ellen A. Nohr Alexander J. Mentzer Tara C. Mills Julian C. Knight Mignon du Plessis Susan Nzenze Jeffrey N. Weiser Julian Parkhill Shabir Madhi Thomas Benfield Anne von Gottberg Arie van der Ende Matthijs C. Brouwer Jeffrey C. Barrett Stephen D. Bentley Diederik van de Beek |
| author_sort |
John A. Lees |
| title |
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis |
| title_short |
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis |
| title_full |
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis |
| title_fullStr |
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis |
| title_full_unstemmed |
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis |
| title_sort |
joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-05-01 |
| description |
Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specific bacterial genetic variation associated with susceptibility. |
| url |
https://doi.org/10.1038/s41467-019-09976-3 |
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doaj-676c4fca20864aaa9d086a45a85f61c32021-05-11T11:29:43ZengNature Publishing GroupNature Communications2041-17232019-05-0110111410.1038/s41467-019-09976-3Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitisJohn A. Lees0Bart Ferwerda1Philip H. C. Kremer2Nicole E. Wheeler3Mercedes Valls Serón4Nicholas J. Croucher5Rebecca A. Gladstone6Hester J. Bootsma7Nynke Y. Rots8Alienke J. Wijmega-Monsuur9Elisabeth A. M. Sanders10Krzysztof Trzciński11Anne L. Wyllie12Aeilko H. Zwinderman13Leonard H. van den Berg14Wouter van Rheenen15Jan H. Veldink16Zitta B. Harboe17Lene F. Lundbo18Lisette C. P. G. M. de Groot19Natasja M. van Schoor20Nathalie van der Velde21Lars H. Ängquist22Thorkild I. A. Sørensen23Ellen A. Nohr24Alexander J. Mentzer25Tara C. Mills26Julian C. Knight27Mignon du Plessis28Susan Nzenze29Jeffrey N. Weiser30Julian Parkhill31Shabir Madhi32Thomas Benfield33Anne von Gottberg34Arie van der Ende35Matthijs C. Brouwer36Jeffrey C. Barrett37Stephen D. Bentley38Diederik van de Beek39Department of Microbiology, New York University School of MedicineAmsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam NeuroscienceAmsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam NeuroscienceParasites and Microbes, Wellcome Sanger InstituteAmsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam NeuroscienceMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College LondonParasites and Microbes, Wellcome Sanger InstituteCentre for Infectious Disease Control, National Institute for Public Health and the EnvironmentCentre for Infectious Disease Control, National Institute for Public Health and the EnvironmentCentre for Infectious Disease Control, National Institute for Public Health and the EnvironmentCentre for Infectious Disease Control, National Institute for Public Health and the EnvironmentDepartment of Pediatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital, University Medical Centre UtrechtDepartment of Pediatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital, University Medical Centre UtrechtAmsterdam UMC, University of Amsterdam, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public HealthDepartment of Neurology, Brain Center Rudolf Magnus, University Medical Center UtrechtDepartment of Neurology, Brain Center Rudolf Magnus, University Medical Center UtrechtDepartment of Neurology, Brain Center Rudolf Magnus, University Medical Center UtrechtDepartment of Microbiological Surveillance and Research, Statens Serum InstitutDepartment of Infectious Diseases, Hvidovre Hospital, University of CopenhagenDepartment of Human Nutrition, Wageningen UniversityAmsterdam UMC, VU University, Department of Epidemiology and Biostatistics, Amsterdam Public HealthAmsterdam UMC, University of Amsterdam, Department of Internal Medicine, Geriatrics, Amsterdam Public HealthCenter for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospitals, The Capital RegionThe Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic GeneticsInstitute of Clinical Research, University of Southern DenmarkWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of OxfordWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of OxfordWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of OxfordSchool of Pathology, Faculty of Health Sciences, University of WitwatersrandSchool of Pathology, Faculty of Health Sciences, University of WitwatersrandDepartment of Microbiology, New York University School of MedicineParasites and Microbes, Wellcome Sanger InstituteNational Institute for Communicable DiseasesDepartment of Infectious Diseases, Hvidovre Hospital, University of CopenhagenSchool of Pathology, Faculty of Health Sciences, University of WitwatersrandAmsterdam UMC, University of Amsterdam, Department of Medical Microbiology, Amsterdam Infection and ImmunityAmsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam NeuroscienceParasites and Microbes, Wellcome Sanger InstituteParasites and Microbes, Wellcome Sanger InstituteAmsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam NeuroscienceStreptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specific bacterial genetic variation associated with susceptibility.https://doi.org/10.1038/s41467-019-09976-3 |