Antiviral Potential of a Novel Compound CW-33 against Enterovirus A71 via Inhibition of Viral 2A Protease

Antiviral Potential of a Novel Compound CW-33 against Enterovirus A71 via Inhibition of Viral 2A Protease

Enterovirus A71 (EV-A71) in the Picornaviridae family causes hand-foot-and-mouth disease, aseptic meningitis, severe central nervous system disease, even death. EV-A71 2A protease cleaves Type I interferon (IFN)-α/β receptor 1 (IFNAR1) to block IFN-induced Jak/STAT signaling. This study investigated...

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Bibliographic Details
Main Authors: Ching-Ying Wang, An-Cheng Huang, Mann-Jen Hour, Su-Hua Huang, Szu-Hao Kung, Chao-Hsien Chen, I-Chieh Chen, Yuan-Shiun Chang, Jin-Cherng Lien, Cheng-Wen Lin
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Viruses
Subjects:
enterovirus A71
2A protease
type I interferon
antagonism
inhibitor
Online Access:http://www.mdpi.com/1999-4915/7/6/2764

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http://www.mdpi.com/1999-4915/7/6/2764

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