Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway

Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway

Lysophosphatidic acid is a small extracellular signaling molecule, which is elevated in pathological conditions such as ischemic stroke and traumatic brain injury (TBI). LPA regulates the survival of neurons in various diseases. However, the molecular mechanisms underlying LPA-induced neuronal death...

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Bibliographic Details
Main Authors: Jie Zhang, Yiyi Li, Chao Wang, Yaya Wang, Yangyang Zhang, Liqin Huang, Zhaohui Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
LPA
LPA1
LPA2
MAPK
apoptosis
mitochondrial dysfunction
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00016/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2020.00016/full

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