A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for treating cancers that lack druggable driver genes. Here we found that human liver cancer was dependent on extracellular glutamine. However, targeting glutamine addiction using the glutaminase inhibitor...

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Bibliographic Details
Main Authors: Haojie Jin, Siying Wang, Esther A Zaal, Cun Wang, Haiqiu Wu, Astrid Bosma, Fleur Jochems, Nikita Isima, Guangzhi Jin, Cor Lieftink, Roderick Beijersbergen, Celia R Berkers, Wenxin Qin, Rene Bernards
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
hepatocellular carcinoma
glutaminolysis
CB-839
glutamine addiction
Online Access:https://elifesciences.org/articles/56749

Internet

https://elifesciences.org/articles/56749

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