Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation

Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation

A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been identified as the pathogen responsible for the outbreak of a severe, rapidly developing pneumonia (Coronavirus disease 2019, COVID-19). The virus enzyme, called 3CLpro or main protease (M<sup>pro</su...

Full description

Bibliographic Details
Main Authors: Simone Di Micco, Simona Musella, Marina Sala, Maria C. Scala, Graciela Andrei, Robert Snoeck, Giuseppe Bifulco, Pietro Campiglia, Alessio Fasano
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
SARS-CoV-2
peptide
FRET
molecular docking
molecular dynamics
MM-GBSA
Online Access:https://www.mdpi.com/1422-0067/22/17/9427

Internet

https://www.mdpi.com/1422-0067/22/17/9427

Similar Items