The Role of Conformational Dynamics in Abacavir-Induced Hypersensitivity Syndrome

Abstract Abacavir is an antiretroviral drug used to reduce human immunodeficiency virus (HIV) replication and decrease the risk of developing acquired immune deficiency syndrome (AIDS). However, its therapeutic value is diminished by the fact that it is associated with drug hypersensitivity reaction...

Full description

Bibliographic Details
Main Authors: James Fodor, Blake T. Riley, Itamar Kass, Ashley M. Buckle, Natalie A. Borg
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-47001-1