The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage

The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage

The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner. RNA-Seq analysis of TFEB/TFE3 double-knockout cells exposed to etopos...

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Bibliographic Details
Main Authors: Owen A Brady, Eutteum Jeong, José A Martina, Mehdi Pirooznia, Ilker Tunc, Rosa Puertollano
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
TFEB
TFE3
p53
lysosomes
DNA Damage
cell cycle
Online Access:https://elifesciences.org/articles/40856

Internet

https://elifesciences.org/articles/40856

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