Wnt5b integrates Fak1a to mediate gastrulation cell movements via Rac1 and Cdc42

Focal adhesion kinase (FAK) mediates vital cellular pathways during development. Despite its necessity, how FAK regulates and integrates with other signals during early embryogenesis remains poorly understood. We found that the loss of Fak1a impaired epiboly, convergent extension and hypoblast cell...

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Bibliographic Details
Main Authors: I-Chen Hung, Tsung-Ming Chen, Jing-Ping Lin, Yu-Ling Tai, Tang-Long Shen, Shyh-Jye Lee
Format: Article
Language:English
Published: The Royal Society 2020-02-01
Series:Open Biology
Subjects:
fak
wnt
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.190273