Role of miR-148a in Mitigating Hepatic Ischemia-Reperfusion Injury by Repressing the TLR4 Signaling Pathway via Targeting CaMKIIα in Vivo and in Vitro

Role of miR-148a in Mitigating Hepatic Ischemia-Reperfusion Injury by Repressing the TLR4 Signaling Pathway via Targeting CaMKIIα in Vivo and in Vitro

Background/Aims: Hepatic ischemia-reperfusion (I/R) injury, which is mainly induced by inflammation and unstable intracellular ions, is a major negative consequence of surgery that compromises hepatic function. However, the exact mechanisms of liver I/R injury have not been determined. Positive cros...

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Bibliographic Details
Main Authors: Daofeng Zheng, Zhongtang Li, Xufu Wei, Rui Liu, Ai Shen, Diao He, Chengyong Tang, Zhongjun Wu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Ischemia-reperfusion injury
Ca2+/calmodulin-dependent protein kinase II (CaMKII)
MicroRNA (miRNA)
Toll-like receptor 4 (TLR4)
Hypoxia/reoxygenation
Online Access:https://www.karger.com/Article/FullText/493716

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https://www.karger.com/Article/FullText/493716

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